目的:系统评价连续性血液净化非计划下机的影响因素，为预防非计划下机提供参考依据。方法:检索中国知网、万方数据库、中国生物医学文献数据库、中文科技期刊全文数据库、PubMed、Web of Science数据库中有关连续性血液净化非计划下机影响因素的文献，中文数据库检索时间为建库至2021年3月，英文数据库2016年3月至2021年3月。由两名研究者独立进行文献筛选、质量评价及资料提取，采用Stata 14.0软件进行Meta分析。结果:共纳入文献11篇，累计连续性血液净化治疗3 031例次，发生非计划下机1 412例次，各影响因素合并n OR值及95%n CI分别为：治疗模式2.22(1.06-4.62)、血流速度0.91(0.76-1.09)、意识躁动4.54(2.33-8.86)、使用呼吸机2.67(1.63-4.38)、输入血制品及脂肪乳1.07(0.34-3.36)、一次性置管成功0.26(0.05-1.42)、置管部位(股静脉比颈静脉)2.24(0.83-6.02)。n 结论:非计划下机受多因素影响，本研究显示治疗模式、意识躁动、使用呼吸机是非计划下机的危险因素；血流速度、输入血制品及脂肪乳、一次性置管成功、置管部位与非计划下机无相关性。“,”Objective:To systematically evaluate the influencing factors on unplanned shutdown of continuous blood purification, and to provide reference basis for the prevention of unplanned shutdown.Methods:The literatures related to the influencing factors of unplanned shutdown of continuous blood purification in CNKI, Wanfang Database, Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database, PubMed and Web of Science were searched.The retrieval time of Chinese database was from the establishment of the database to March 2021.English databases were searched from March 2016 to March 2021.Literature selection, quality evaluation and data extraction were independently conducted by two researchers, and Meta-analysis was performed by Stata 14.0 software.Results:A total of 11 studies were included, including 3 031 cases of continuous blood purification treatment and 1 412 cases of unplanned discontinuation.The combined n OR value and 95%n CI of all influencing factors were as follows: treatment mode 2.22 (1.06-4.62), blood flow velocity 0.91 (0.776-1.09), agitation 4.54 (2.33-8.86), ventilator 2.67 (1.63-4.38), transfusing blood products and fat milk 1.07 (0.34-3.36), one-time catheter success 0.26 (0.05-1.42), catheterization site (femoral vein vs.jugular vein) 2.24 (0.83-6.02).n Conclusion:Unplanned deplaning is influenced by many factors.Treatment mode, agitation and ventilator use are the risk factors for unplanned deplaning.There is no correlation between blood flow velocity, transfusing blood products and fat milk, one-time catheterization success, catheterization site and unplanned deplaning.