论文部分内容阅读
本文报道在泰国曼谷东北部抗氯喹的恶性疟和间日疟高度流行区用各种剂量的盐酸甲氟喹[WR142,490,左旋-赤络-α-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇]和周效磺胺-乙胺嘧啶(S-Py)合剂进行预防疟疾感染的现场试验。将990名10岁以上的受试者,不包括15~44岁的妇女,随机分成6个组。第1组每两周眼S(1,000mg)-Py(50mg);第2组每周服S(500mg)-Py(25mg);第3组每周服甲氟喹180mg,儿童(22~35kg)为1/2剂量;第4组每2周服甲氟喹360mg,儿童为1/4剂量;第5组每周服甲氟喹360mg,儿童为1/4剂量;第6组服安慰剂。每周家访送药。为了保持双盲性质,每个受
This article reports the use of various doses of mefloquine hydrochloride [WR142,490, levodopa-alpha-2-piperidinyl-2,8-d] pyrimidine against chloroquine-resistant P. falciparum and P. vivax in northeastern Bangkok, Bis (trifluoromethyl) -4-quinolinemethanol] and psoralens-pyrimethamine (S-Py) were tested in a field trial to prevent malaria infection. 990 subjects over the age of 10, excluding women aged 15-44, were randomized into 6 groups. Group 1 received S (1,000mg) -Py (50mg) every two weeks; Group 2 received weekly S (500mg) -Py (25mg); Group 3 received metconazole 180mg and children (22-35kg) 1/2 dose; group 4 every 2 weeks mefloquine 360mg, children 1/4 dose; group 5 weekly mefloquine 360mg, children 1/4 dose; group 6 placebo. Weekly home delivery. In order to maintain the double-blind nature of each subject