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目的调查我院I类切口手术围术期预防用抗菌药物情况。方法抽取我院516份I类切口手术出院病历，根据抗菌药物合理应用评价标准，对其适应证、药物选择、用药时间、溶媒选择、用法用量、联合用药等情况进行统计、分析。结果516份I类切口手术病历中494例使用抗菌药物，使用率为95.7%；其中切皮前30min~2h内给药的421例，占85.2%；预防性应用抗菌药物共涉及8类17种，应用频次排序列前3位的依次为头孢一代(206例，41.7%)、头霉素(188例，38.1%)、青霉素(47例，9.5%)；单一用药491例(99.4%)，二联联合用药3例(0.6%)；56.3%的患者预防用抗菌药物疗程超过24h。结论我院I类切口手术围手术期预防应用抗菌药物存在不合理现象，需制订完善的围手术期预防用药管理措施。“,”Objective To investigate the prophylactic use of antibiotics for class I incision surgery in my hospitals.Methods A total of 516 patients who received class I incision surgery in my hospitals.According to evaluation standards for rational use of antibiotics,the indication,selection of antibiotics,timing of drug use,proper selection of solvent,usage and dosage,drug combination were analyzed statistical y.Results Among 516 patients,494 patients underwent clean surgery were treated with antibacterials(95.7%).421 patients(85.2%)were received antibiotics in 30min~2 h before the operation.8 categories and 17 kinds of antibiotics were used in the typeⅠincision operation.The first 3 drugs in the list of frequency were first generation cephalosporins (206 cases),cephamycins(188 cases)and penicil ins (47 cases).491 cases received single kind of antibiotics (99.4%)and 3 cases combination ofantibiotics (0.6%).56.3%patients’perioperative period antibiotic prophylaxis course were over 24h.Conclusion There exists ir ational phenomenon in the preoperative application of antibiotics for class I incision surgery,develop complete measures for prophylactic use of antibiotics.