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目的探讨脑血管病（CVD）患者血浆β－内啡肽含量与CVD的发病关系。方法用放射免疫方法测定了经头颅CT确诊的32例脑出血患者和42例脑梗塞患者及年龄相当的30例正常人血浆β－内啡肽含量。结果显示CVD组中β－内啡肽含量显著高于对照组，且以脑梗塞组增高最显著（P均＜0．001）。结论提示β－内啡肽与CVD发病过程有关，在CVD患者及CVD高危人群中观察β－内啡肽变化对CVD的诊断与防治具有重要临床意义。
Objective To investigate the relationship between plasma β-endorphin and CVD in patients with cerebrovascular disease (CVD). Methods The plasma levels of β-endorphin in 32 patients with cerebral hemorrhage and 42 patients with cerebral infarction who were diagnosed by head CT and 30 normal controls were determined by radioimmunoassay. The results showed that the content of β-endorphin in CVD group was significantly higher than that in control group, and the most significant increase was in cerebral infarction group (all P <0.001). The results suggest that β-endorphin is involved in the pathogenesis of CVD. It is of great clinical significance to observe the changes of β-endorphin in CVD patients and high-risk CVD patients for the diagnosis and prevention of CVD.