瘦素是近年发现的肥胖基因 (ｏｂ基因 )的表达产物 ,由脂肪细胞分泌 ,具有促进产热及抑制食欲的功能 ,是机体维持正常体重不可缺少的激素。肥胖者表现高瘦素血症 ,且易发生糖代谢异常 ,是糖尿病发病的独立危险因素。本研究观察不同剂量的瘦素对肝细胞基础状态和胰岛素刺激下对 Leptin is an expression product of the obesity gene (ob gene) found in recent years. It is secreted by adipocytes and has functions of promoting fever and suppressing appetite. It is an indispensable hormone for maintaining normal body weight. Obesity, high leptinosis, and prone to abnormal glucose metabolism, is an independent risk factor for the onset of diabetes. This study observed different doses of leptin on basal state of hepatocytes and insulin stimulation