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目的:探讨卡培他滨联合参芪扶正注射液对食管癌术后患者VEGF表达及不良反应发生率和生活质量的影响。方法:选取我院收治的食管癌术后患者90例,根据治疗方案不同分为对照组及实验组,对照组以常规化疗,实验组化疗联合参芪扶正注射液治疗。比较各组患者治疗前后生活质量及血管内皮生长因子VEGF表达水平,治疗后副反应发生率、肝肾功损害变化情况。结果:与治疗前比较,治疗后两组躯体、社会及QOL评分、疲乏评分及睡眠水平均降低(P<0.05),QOL评分、尿素氮及肌酐均升高(P<0.05),治疗后与对照组比较,实验组躯体、社会、睡眠及疲乏评分、生活质量、血象较高(P<0.05),实验组消化道反应、脱发时间较短,肌酐及尿素氮水平及VEGF水平较低(P<0.05)。结论:卡培他滨联合参芪扶正注射液可减轻化疗对患者体质、睡眠、社会功能、生活质量等水平的影响,保护肝肾功能,减轻脱发、恶心呕吐等副反应症状,降低VEGF水平,临床疗效优于传统方案,可作为临床有效治疗方案。
Objective: To investigate the effects of capecitabine combined with Shenqi Fuzheng injection on the incidence of VEGF, adverse reactions and quality of life in postoperative patients with esophageal cancer. Methods: 90 cases of esophageal cancer patients treated in our hospital were selected and divided into control group and experimental group according to different treatment regimen. The control group was treated with routine chemotherapy and experimental group combined with Shenqi Fuzheng injection. The quality of life and the expression of vascular endothelial growth factor VEGF before and after treatment in each group were compared, the incidence of side effects after treatment, changes in liver and kidney function were compared. Results: Compared with those before treatment, the somatic, social and QOL scores, fatigue scores and sleep levels of both groups decreased (P <0.05), QOL score, urea nitrogen and creatinine increased (P <0.05) Compared with the control group, the physical, social, sleep and fatigue scores, quality of life and blood of the experimental group were higher (P <0.05). The experimental group had shorter digestive reaction, shorter hair loss time, lower creatinine and urea nitrogen levels and lower VEGF <0.05). Conclusion: Capecitabine combined with Shenqi Fuzheng injection can reduce the influence of chemotherapy on physique, sleep, social function and quality of life of patients, protect liver and kidney function, alleviate side effects such as alopecia, nausea and vomiting, reduce VEGF level, Clinical efficacy is better than the traditional program, can be used as a clinically effective treatment.