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目的观察两种剂量奥曲肽治疗食管、胃底静脉曲张出血的疗效和安全性。方法急诊及住院病人70例,随机分为奥曲肽50μg/h组(n=35)、奥曲肽25μg/h组(n=35)。结果止血时间50μg/h组为(13.4±11.2)h,明显快于25μg/h组的(19.8±16.2)h;6 h、12 h、24 h、48 h和72 h止血率50μg/h组分别为51.4%、71.4%、85.7%、91.4%和94.3%;明显高于25μg/h组的40.0%、53.7%、71.4%、82.9%和85.7%(P<0.05);平均输血量50μg/h组为(420±305)mL,少于25μg/h组的(580±463)mL(P<0.05)。再出血率50μg/h组为11.4%,明显低于25μg/h组的22.%(P<0.05)。两组均无明显不良反应报告。结论两种剂量的奥曲肽对食管、胃底静脉曲张出血均有效,50μg/h组疗效优于25μg/h组,且止血时间快,再出血率低。
Objective To observe the efficacy and safety of two doses of octreotide in the treatment of esophageal and gastric varices bleeding. Methods A total of 70 emergency and inpatient patients were randomly divided into 5 groups: octreotide 50μg / h (n = 35) and octreotide 25μg / h (n = 35). Results The hemostatic time in the 50μg / h group was (13.4 ± 11.2) h, which was significantly faster than that in the 25μg / h group (19.8 ± 16.2) h. The hemostatic rate was 50μg / h at 6 h, 12 h, 24 h, 48 h and 72 h (51.4%, 71.4%, 85.7%, 91.4% and 94.3% respectively), significantly higher than those of 25μg / h group (40.0%, 53.7%, 71.4%, 82.9% and 85.7% (420 ± 305) mL in h group and (580 ± 463) mL in less than 25μg / h group (P <0.05). The rebleeding rate was 11.4% in the 50μg / h group, which was significantly lower than 22% in the 25μg / h group (P <0.05). No adverse reaction was reported in both groups. Conclusion Both doses of octreotide are effective for esophageal and gastric variceal hemorrhage. The effect of 50μg / h is better than that of 25μg / h group, and the bleeding time is fast and the rate of rebleeding is low.