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目的了解女性类风湿关节炎患者POF的发生率,探讨TGF-β在类风湿关节炎(RA)并发卵巢早衰(POF)的作用及其相关实验室指标的临床分析。方法选择2015年1月-2016年12月确诊的女性类风湿关节炎(符合2009年ACR诊断标准)230例,进一步将其分为RA组与类风湿关节炎并发卵巢早衰组(RA-POF组);收集同期妇产科门诊健康育龄体检者50例为对照组,年龄匹配。分别检测RA组、RA-POF组及对照组女性性激素(FSH、LH、E2)水平及TGF-β水平。结果女性RA患者230例中出现卵巢早衰者29例(12.6%)。与正常对照组及RA组比较,RA-POF组FSH明显升高,E2明显下降,差异具有统计学意义,P<0.05。与正常对照组比较,RA-POF组血清TGF-β水平降低,P<0.05。结论女性RA患者发生卵巢早衰临床中并不少见,检测血清FSH、LH、E2、TGF-β可以反应卵巢功能情况,临床中应重视并及早发现,及时进行药物干预,减少RA并发POF。
Objective To investigate the prevalence of POF in women with rheumatoid arthritis and to explore the role of TGF-β in the pathogenesis of rheumatoid arthritis (RA) complicated with premature ovarian failure (POF) and the clinical analysis of related laboratory parameters. Methods 230 patients with rheumatoid arthritis (accordant with 2009 ACR diagnostic criteria) diagnosed from January 2015 to December 2016 were selected and further divided into RA group and rheumatoid arthritis patients with premature ovarian failure (RA-POF group) ); Collect the obstetrics and gynecology outpatient health check-up examination in the same period 50 patients as control group, age-matched. The levels of sex hormones (FSH, LH, E2) and TGF-β in female RA, RA-POF and control groups were detected. Results Among the 230 women with RA, 29 cases (12.6%) had premature ovarian failure. Compared with the normal control group and the RA group, FSH in RA-POF group was significantly increased, E2 was significantly decreased, the difference was statistically significant, P <0.05. Compared with the normal control group, serum TGF-β level decreased in RA-POF group, P <0.05. Conclusions It is not uncommon for women with RA to develop premature ovarian failure. Detecting serum FSH, LH, E2 and TGF-β may reflect the ovarian function. In clinic, attention should be paid to the early detection of ovarian premature ejaculation. Drug intervention and POF should be reduced in time.