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目的:探讨四川地区非霍奇金淋巴瘤(NHL)与乙型肝炎病毒(HBV)感染的关系。方法:对160例NHL患者临床资料进行回顾性分析,应用ELISA方法测定确诊NHL时患者的乙型肝炎病毒两对半情况,并随机抽取同期住院的160例其他恶性肿瘤患者(排除原发肝细胞肝癌),160例健康体检者作为对照进行比较。结果:160例NHL患者伴HBV感染者39例(占45%),其他恶性肿瘤患者HBV感染者19例(占11.9%),健康体检者HBV感染者17例(占10.6%),与肿瘤对照组和健康对照组相比,NHL组HBV感染率高于该两组,差异有统计学意义(P<0.05)。而两对照组间比较,差异无统计学意义(P>0.05)。Ⅲ期和Ⅳ期NHL患者HBV感染率明显高于Ⅰ期和Ⅱ期患者,差异有统计学意义(P<0.05)。结论:四川地区NHL患者中HBV感染率高于一般人群和非原发性肝细胞肝癌肿瘤患者,HBV感染与NHL发病有一定相关性。
Objective: To investigate the relationship between non-Hodgkin’s lymphoma (NHL) and hepatitis B virus (HBV) infection in Sichuan Province. Methods: The clinical data of 160 patients with NHL were analyzed retrospectively. ELISA was used to determine the two-and-a-half cases of hepatitis B virus in patients with NHL. A total of 160 patients with other malignant tumors (excluding primary hepatocytes Liver cancer), 160 healthy subjects were compared as a control. Results: Among 160 patients with NHL, 39 (45%) were infected with HBV, 19 (11.9%) were HBV infection, and 17 (10.6%) were HBV infection in other malignant tumors. Compared with the healthy control group, the HBV infection rate in NHL group was higher than the two groups, the difference was statistically significant (P <0.05). There was no significant difference between the two control groups (P> 0.05). The HBV infection rates of stage III and stage IV NHL patients were significantly higher than those of stage I and II patients (P <0.05). Conclusion: The prevalence of HBV in NHL patients in Sichuan Province is higher than that in the general population and non-HCC patients. There is a certain correlation between HBV infection and the incidence of NHL.