川楝素(toosendanin)对小鼠和猴肉毒中毒有治疗效果。作者曾报道,正常大鼠给川楝素后能引起神经肌肉接头(N M J)突触小泡(synaptic vesicle)减少等超微结构改变。本实验的目的在于观察肉毒中毒小鼠给川楝素后膈肌 N M J 超微结构的变化。通过对大量 N M J 在电子显微镜下直接观察和照相底片上的测量,我们发现,肉毒中毒小鼠在有效和无效 Toosendanin has a therapeutic effect on botulism in mice and monkeys. The authors have reported that normal rats can induce ultrastructural changes such as reduction of synaptic vesicles in neuromuscular junctions (N M J ) after administration of buprenorphine. The purpose of this experiment was to observe the ultrastructural changes of N M J in the phrenic muscle following botulism in mice. By directly observing large amounts of N M J under electron microscope and measuring on photographic negatives, we found that botulism mice were effective and ineffective