3,4-亚甲基二氧基甲基苯丙胺(MDMA)是近年来在全世界,特别是亚洲地区公共娱乐场所流行性滥用的“摇头丸”的主要药物成分。MDMA主要作用于人体神经系统从而表现出各种神经系统症状。目前的实验研究发现,MDMA对人体多个系统具有毒性作用,其中对心血管系统的毒性损害作用较为显著。本文就近年来针对MDMA心肌毒性机制的法医毒理学研究进展进行综述,为进一步深入研究提供理论信息。 3,4-Methylenedioxymethamphetamine (MDMA) is the main drug ingredient “ecstasy” that has been abused in public places around the world in recent years especially in Asia. MDMA mainly acts on the human nervous system to exhibit various neurological symptoms. The current experimental study found that MDMA has toxic effects on a number of human systems, of which the damage to the cardiovascular system is more pronounced. This review summarizes recent advances in forensic toxicology research on the mechanism of myocardial toxicity of MDMA, providing theoretical information for further research.