家族性癌的研究虽然涉及多学科、多种研究体系,但是组织病理学所作的贡献正逐渐受到重视。因为无论是临床的还是基础的研究都需要得到组织病理学证实。组织病理学研究的材料来源有两种:回顾性的病例分析和利用存档的石蜡包埋组织块获取DNA的信息。前者可获得丰富的背景资料,特别是几个似无关联的病变出现在同一具尸检结果中。后者则可为家族性癌提供分子生物学的证据。 Although the study of familial cancer involves multiple disciplines and multiple research systems, the contribution of histopathology is gradually receiving attention. Because both clinical and basic research needs to be confirmed by histopathology. There are two sources of materials for histopathological studies: retrospective case analysis and the use of archived paraffin-embedded tissue blocks to obtain DNA information. The former can obtain a wealth of background information, in particular, a few unrelated lesions appear in the same autopsy results. The latter can provide evidence of molecular biology for familial cancer.