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Using endothelin-1 (ET-1) antagonists BQ123 and BQ610. we tested whether endogenous ET-1 contributes to ischemia / re-perfusion injury in isolated. Langendorff rat hearts. BQ123 (7μg/min) and BQ610 (1.75μg/ min) did not affect mechanical function or coronary flow and shifted the dose-response curves for ET-1 (boluses of 4-400 pmol) significantly to the right. Isovolumic rat hearts were
We tested whether endogenous ET-1 contributes to ischemia / re-perfusion injury in isolated Langendorff rat hearts. BQ123 (7 μg / min) and BQ610 (1.75 μg / min) did not affect mechanical function or coronary flow and shifted the dose-response curves for ET-1 (boluses of 4-400 pmol) significantly to the right. Isovolumic rat hearts were