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目的分析糖尿病患者糖化血红蛋白(HbA1c)与空腹血糖(FPG)水平变化及其相关性。方法选取医院收治的糖尿病患者105例为研究对象,采用高效液相色谱法与葡萄糖氧化酶法分别检测患者HbA1c、FPG指标,按照HbA1c水平将糖尿病患者分为HbA1c正常组与HbA1c异常组,与我院40例健康医务工作志愿者正常血生化指标进行比较。结果在不同HbA1c水平中均与FPG具有明显相关性,两者指标水平呈正性趋势发展(r=0.579,P=0.0145)。糖尿病患者HbA1c、FPG指标均明显高于健康参照组,差异有统计学意义(P<0.01)。结论 HbA1c作为糖尿病诊断过程中具有良好稳定性数据指标,避免仅单一性空腹血糖检测可能存在的误差,通过联合检测提高诊断全面性。
Objective To analyze the changes of glycosylated hemoglobin (HbA1c) and fasting blood glucose (FPG) in diabetic patients and their correlations. Methods A total of 105 diabetic patients treated in our hospital were enrolled in this study. HbA1c and FPG were detected by high performance liquid chromatography and glucose oxidase method respectively. Patients with diabetes were divided into HbA1c normal group and HbA1c abnormal group according to HbA1c level, Hospital 40 cases of health work volunteers normal blood biochemical indicators were compared. The results showed significant correlation with FPG in different levels of HbA1c, and both indicators showed a positive trend (r = 0.579, P = 0.0145). The indexes of HbA1c and FPG in diabetic patients were significantly higher than those in healthy controls (P <0.01). Conclusion HbA1c as a good indicator of stability during the course of diabetes mellitus can avoid the possible error of single fasting blood glucose test and improve the comprehensiveness of diagnosis through joint detection.