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目的:探讨宣肺止嗽方的镇咳化痰作用及其机理。方法:采用氨水引咳法、酚红排泌法观察宣肺止嗽方对小鼠的镇咳、化痰作用;烟熏法复制慢支模型,观察该方对慢支小鼠肺组织病理形态的影响。结果:宣肺止嗽方可延长小鼠咳嗽潜伏期,高剂量作用显著(P<0.05);抑制小鼠咳嗽次数,高、中剂量效果明显(P<0.01),低剂量无统计学差异,呈现一定的量效关系;明显增加小鼠气管酚红排泌量(P<0.01),亦表现出量效关系;减少慢支模型小鼠肺组织病理形态改变。结论:宣肺止嗽方具有镇咳化痰及减轻慢支模型小鼠肺部炎症改变的作用,提示该方镇咳化痰的作用机理可能与缓解气管炎症有关。
Objective: To investigate the antitussive and phlegm action mechanism of Xuanfei Zhisuo Recipe. Methods: Ammonia induced cough method, phenol red excretion was used to observe the antitussive and phlegm-induced effect of Xuanfei Zhaofu in mice. The model of chronic bronchitis was established by smoked method, and the pathological changes of lung tissues in chronic bronchitis mice were observed. Impact. Results: Xuanfei Cough could prolong the latent period of cough in mice with high dose (P <0.05), inhibit the number of cough in mice with high and medium doses (P <0.01), and there was no significant difference between the two groups (P <0.01). The dose-effect relationship was also observed. The pathological changes of the lung tissue in the chronic bronchitis model mice were also reduced. Conclusion: Xuanfei Zhisuo Decoction has the effects of relieving cough and resolving phlegm and relieving lung inflammation in mice with chronic bronchitis model. It suggests that the mechanism of antitussive and resolving phlegm may be related to the relief of tracheal inflammation.