【摘 要】
：
目的:观察沙利度胺联合联合干扰素α-2b方案治疗原发性骨髓纤维化的疗效及其不良反应。方法:对11例初始原发性骨髓纤维化患者使用沙利度胺治疗,治疗起始量为200mg/天,每晚口
【机 构】
：
河北省邯郸市第一医院血液内科,河北省邯郸市第一医院放射科,河北省邯郸市第一医院输血科,河北省邯郸市第一医院急诊科,河北省邯郸市第一医院超声科,河北省邯郸市第一医院中西医结合科,
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目的:观察沙利度胺联合联合干扰素α-2b方案治疗原发性骨髓纤维化的疗效及其不良反应。方法:对11例初始原发性骨髓纤维化患者使用沙利度胺治疗,治疗起始量为200mg/天,每晚口服,根据患者耐受情况逐渐加量,每周200mm递增,直到800mg/天维持治疗。根据治疗前后白细胞计数、血红蛋白测定、血小板计数、脾脏大小的变化来评定疗效。结果:总有效率为91.0%,无不能耐受的不良反应。结论:沙利度胺联合干扰素α-2b可作为治疗原发性骨髓纤维化有效的治疗方法。
Objective: To observe the efficacy and adverse reactions of thalidomide combined with interferon α-2b in the treatment of primary myelofibrosis. Methods: Eleven patients with initial primary myelofibrosis were treated with thalidomide. The initial dose was 200mg / day. Oral administration was given every night. The dosage was gradually increased according to patient tolerance and increased by 200mm per week until 800mg / Day maintenance treatment. According to the treatment before and after the white blood cell count, hemoglobin determination, platelet count, spleen size changes to assess the efficacy. Results: The total effective rate was 91.0%, no unacceptable adverse reactions. Conclusion: Thalidomide combined with interferon α-2b can be used as an effective treatment for primary myelofibrosis.
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