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目的:为探讨对晚期进展期胃癌,进行胃动脉化疗栓塞并腹腔化疗双途径给药的可行性及临床疗效.方法:无法手术切除的进展期胃癌98例,随机分为三组,A组行胃动脉化疗栓塞并腹腔化疗;B组行腹腔化疗;c组行静脉化疗.结果:胃动脉化疗栓塞是可行的.A、B、C三组有效率分别为71.88%、38.7%和14.3%.A组与B、C组比较有明显差异(P<0.01).A组有5例完全缓解,且生存期延长.不良反应以胃肠道毒性和骨髓抑制为主.A组术后胃粘膜有损伤,四周后可恢复正常.结论:胃动脉化疗栓塞并腹腔化疗双途径给药是治疗晚期进展期胃癌的有效方法.
OBJECTIVE: To investigate the feasibility and clinical efficacy of dual route administration of gastric arterial chemoembolization and intraperitoneal chemotherapy for advanced gastric cancer. Methods: Ninety-eight cases of advanced gastric cancer that cannot be surgically removed were randomly divided into three groups. Gastric arterial chemoembolization and intraperitoneal chemotherapy; Group B was treated with intraperitoneal chemotherapy; Group C was treated with intravenous chemotherapy. Results: Gastric arterial chemoembolization was feasible. The effective rates of the three groups A, B, and C were 71.88%, 38.7%, and 14.3%, respectively. There was a significant difference between group A and group B and group C (P<0.01). There was complete remission in group A and the survival time was prolonged. Adverse reactions were mainly gastrointestinal toxicity and myelosuppression. Group A had gastric mucosa after operation. The injury can be returned to normal after four weeks. Conclusion: Gastric arterial chemoembolization and intraperitoneal chemotherapy dual route administration is an effective method for advanced advanced gastric cancer.