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目的探讨药物不良反应发生的特点,以促进合理用药。方法对开封市第一人民医院2010-01-2010-0646例药物不良反应报告进行评价,从患者一般情况、用药途径、药品种类、药物不良反应(ADR)所致器官损害等方面进行分析。结果 46例药物不良反应中,男性比女性多,45岁以上患者发生的药物不良反应多于其他年龄段;46例药物不良反应报告中涉及药物41种,其中抗感染药物18种,占43.9%,居首位,其次为中药制剂10种,占24.4%,药物不良反应的临床表现以皮肤损害为主,胃肠道反应和神经系统损害次之。结论临床根据患者具体情况,合理使用抗生素;用药前要询问患者的过敏史,用药后认真观察,减少不良反应发生。
Objective To explore the characteristics of adverse drug reactions to promote rational drug use. Methods First Affiliated Hospital of Kaifeng City, 2010-01-2010-0646 cases of adverse drug reactions reported to evaluate the patient’s general situation, route of administration, type of drug, adverse drug reactions (ADR) caused by organ damage were analyzed. Results 46 cases of adverse drug reactions in males than in females, more than 45 years of age patients with adverse drug reactions occurred more than other age groups; 46 cases of drug adverse reactions reported in 41 kinds of drugs, of which 18 kinds of anti-infective drugs, accounting for 43.9% , Ranking first, followed by 10 kinds of Chinese medicine preparations, accounting for 24.4%. The clinical manifestations of adverse drug reactions were mainly skin damage, followed by gastrointestinal reaction and nervous system damage. Conclusions Clinical according to the specific circumstances of patients, the rational use of antibiotics; before treatment to ask the patient’s history of allergies, careful observation after medication to reduce adverse reactions.