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目的:调查相同人群HPV连续3年的感染情况,了解深圳妇女HPV3年累计感染率、转阴率、3年持续感染率,为防治宫颈癌提供依据。方法:收集2004、2005、2006年连续3年均在我单位妇女体检中心妇检的固定人群,同时进行宫颈液基细胞学(LCT)和宫颈分泌物13种高危型人乳头瘤病毒检测,对其中LCT≥宫颈不典型鳞状上皮细胞(ASCUS)和/或人乳头瘤病毒(+)女性进行阴道镜检查及宫颈活体组织检查。结果:该固定人群2004、2005、20063年HPV阳性率分别为18·12%、17·49%、18·34%;3年该人群的累计感染率为29·49%;转阴率为<35岁为76·26%(151/198)、≥35岁为23·74%(47/198);持续感染率为56·18%(300/534)。结论:深圳地区HPV感染情况比宫颈癌高发区低,但感染状况不容乐观,年轻、性生活活跃者较易感染高危型HPV且易于清除;对HPV感染的忽视与过分恐惧都是不适宜的;目前最为理想、且能从根本上防范子宫颈癌的办法是采用疫苗进行预防。
OBJECTIVE: To investigate the infection status of HPV in the same population for 3 consecutive years and to understand the cumulative frequency of infection, negative conversion rate and 3-year persistent infection rate of HPV3 in Shenzhen women and provide basis for prevention and treatment of cervical cancer. Methods: We collected fixed population of women who had been in the women’s physical examination center in our hospital for three consecutive years in 2004, 2005 and 2006. Meanwhile, we detected 13 high risk human papillomavirus (LCT) and cervical secretions Among them LCT ≥ cervical atypical squamous cell (ASCUS) and / or human papillomavirus (+) women colposcopy and cervical biopsy. Results: In 2004, 2005 and 20063, the positive rate of HPV was 18.12%, 17.49% and 18.34% respectively in this fixed population. The cumulative infection rate in this population was 29.49% at 3 years. The negative conversion rate was < 76 · 26% (151/198) at 35 years of age, 23 · 74% (35/19) at 35 years of age; and persistent infection rate of 56 · 18% (300/534). Conclusion: The prevalence of HPV infection in Shenzhen is lower than that of cervical cancer, but the infection status is not optimistic. The young and active sex life are more likely to be infected with high risk HPV and are easy to remove. Neglecting and overfeeding HPV infection is not suitable. Currently the most ideal, and can fundamentally prevent cervical cancer approach is to use vaccines for prevention.