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[目的]探讨全麻复合硬膜外麻醉对子痫前期患者凝血功能相关指标的影响.[方法]60例子痫前期患者,随机分为两组,各30例,对照组在剖宫产术前给予全身麻醉,观察组实施全麻复合硬膜外麻醉,比较两组麻醉前(T0)、麻醉平稳后(T1)、术中30 min(T2)、术后24 h(T3)的平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)及各时点活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D),并观察并发症发生情况.[结果]观察组麻醉诱导时间短于对照组,麻黄碱用量多于对照组(P<0.05);观察组T1、T2、T3时 MAP、HR低于,T1、T2时 SpO2高于对照组(P<0.05);观察组 T1、T2、T3时APTT长于对照组,FIB、D-D水平低于对照组,两组各时点PT对比差异无显著性(P<0.05);观察组麻醉相关并发症发生率低于对照组(P<0.05).[结论]全麻复合硬膜外麻醉对子痫前期患者凝血功能、血流动力学指标,可缩短麻醉诱导时间,减少相关并发症,值得在临床推广应用.“,”[Objective]To explore the effects of general anesthesia combined with epidural anesthesia on coagulation function in preeclampsia patients.[Methods]A total of 60 preeclampsia patients were divided into two group,with 30 cases in each group.The control group was given general anesthesia before cesarean sec-tion,and the observation group was treated with general anesthesia combined with epidural anesthesia.The levels of MAP,HR,SpO2and APTT(activated partial prothrombin time),PT(prothrombin time),FIB(fi-brinogen)and D-D(D-dimer)at the time before anesthesia(T0),after anesthesia was stable(T1),intraoper-ative 30min(T2),postoperative 24h(T3)were compared between the two groups.The complications were observed as well.[Results] The anesthesia induction time in the observation group was shorter and the ephed-rine dosage was more than that of the control group(P <0.05),The levels of MAP and HR at the time point of T1,T2and T3were lower,and the level of SpO2at the time point of T1and T2were higher in the observa-tion group than those in the control group(P <0.05).The APTT was longer in the observation group than in the control group at the time point of T 1,T2and T3,and the levels of FIB and D-D were lower in the observa-tion group than in the control group.There was no significant difference in the PT at each time point in the two groups(P <0.05).The incidence rate of complications related to anesthesia in the observation group was low-er than that in the control group.[Conclusion]General anesthesia combined with epidural anesthesia has little influence on blood coagulation function,hemodynamic index in preeclampsia patients.It can shorten the anes-thesia induction time and reduce related complications.Therefore it is worthy of clinical application.