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目的:考察活络通脑片对脑卒中的预防作用。方法:建立大鼠双侧颈总动脉结扎再灌注损伤模型和栓线法致大鼠局灶性脑缺血-再灌注损伤模型,分别观察活络通脑片对这2种脑卒中动物模型的影响。结果:活络通脑片能显著减轻2种模型大鼠脑组织病理学损伤改变,提高模型大鼠脑组织/血清SOD活性并降低MDA含量;并能有效降低双侧颈总动脉结扎再灌注模型大鼠的脑含水量,有效改善大脑中动脉阻塞再灌注模型大鼠行为学指标及脑梗死范围。结论:预防性给予活络通脑片对脑卒中模型大鼠有一定的保护作用。
Objective: To investigate the preventive effect of Huoluo Tongnai Tablet on stroke. Methods: The models of bilateral common carotid artery ligation and reperfusion injury and focal cerebral ischemia-reperfusion injury in rats were established, and the effects of “Huoluo Tongnao Tablet” on the two models of stroke were observed . Results: Huoluo Tongnao Tablet can significantly reduce the pathological changes in the brain tissue of the two models, increase the activity of SOD and decrease the content of MDA in the brain tissue / serum of the model rats, and can effectively reduce the model of bilateral common carotid artery ligation and reperfusion Rat brain water content, effectively improve the middle cerebral artery occlusion reperfusion model of behavioral indicators and cerebral infarction range. Conclusion: Preventive administration of Huoluo Tongnao Tablet can protect rats with stroke model.