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目的比较舒通胶囊和麻仁软胶囊对便秘大鼠大肠推进功能的影响。方法正常Wistar大鼠60只,随机分为舒通胶囊和麻仁软胶囊各高、中、低3个剂量组,每组10只。分别灌胃舒通胶囊(2.0,1.0,0.5g/kg)和麻仁软胶囊(1.8,1.2,0.6g/kg);另取Wistar大鼠80只,喂饲大米、禁水3d制备燥结便秘大鼠模型,随机分为舒通胶囊和麻仁软胶囊各4个剂量组,每组10只。分别灌胃舒通胶囊(4.0,2.0,1.0,0.5g/kg)和麻仁软胶囊(2.4,1.8,1.2,0.6g/kg);给药后,正常和模型大鼠均开腹由回盲部注入墨汁生理盐水混合液2ml/100g,观测各组大鼠大肠墨汁推进百分率,作量效曲线并比较两药的效价强度及效能。结果舒通胶囊对正常大鼠大肠推进作用不存在量效正相关;舒通胶囊对燥结便秘大鼠可明显增强大鼠大肠推进功能,且呈量效正相关性,其效价强度和效能均大于麻仁软胶囊,但效能差异无统计学意义(P>0.05)。结论舒通胶囊增强燥结便秘大鼠大肠的推进功能与麻仁软胶囊相当。
Objective To compare the effects of Shu Tong Capsule and Maren Capsule on the function of large intestine in constipation rats. Methods Sixty normal Wistar rats were randomly divided into 3 groups: high dose, middle dose and low dose of Shentong Capsule and Maren Capsule, with 10 rats in each group. (2.0,1.0,0.5g / kg) and Maren Capsule (1.8,1.2,0.6g / kg) respectively. Another 80 Wistar rats were fed with rice and water-dried for 3 days Constipation rat model were randomly divided into 4 doses of Shu Tong Capsule and Maren Capsule, 10 in each. The mice were randomly divided into four groups: Shu Tong Capsule (4.0,2.0,1.0,0.5g / kg) and Maren Capsule (2.4,1.8,1.2,0.6g / kg) Blind part of the ink into the saline mixture 2ml / 100g, observe the percentage of rats in each group of large intestine ink for dose-effect curve and compare the potency and potency of the two drugs. Results Shu Tong Capsule had no effect on the quantity and effect of large intestine propulsion in normal rats. Shu Tong Capsule could significantly promote the function of large intestine propulsion in rats with constipation and constipation, and showed a dose-effect and a positive correlation. The potency and potency Are larger than Maren soft capsules, but no significant difference in efficacy (P> 0.05). Conclusion Shutong capsule enhances the promotion function of large intestine of constipation constipation rats with Maren soft capsules.