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现已发现两型１１β羟基类固醇脱氢酶（１１βＨＳＤ）：１１βＨＳＤ１为氧化还原酶，催化皮质醇与其代谢产物之间的相互转化；１１βＨＳＤ２则为专一氧化酶，只催化皮质醇的失活。１１βＨＳＤ１在体内分布广泛，功能目前尚不清楚。１１βＨＳＤ２主要存在于盐皮质激素靶器官，肾脏１１βＨＳＤ２通过降解糖皮质激素保护盐皮质激素受体的特异性，肾脏此酶的缺乏，可以导致严重高血压。胎盘１１βＨＳＤ２通过降解母体高浓度的糖皮质激素保证胎儿的正常发育，胎盘此酶的异常可以导致胎儿宫内发育迟缓。此酶还可能与应激、糖尿病、退行性神经变性等有关
It has been found that two types of 11β-hydroxysteroid dehydrogenase (11β-HSD): 11β-HSD1 is an oxidoreductase that catalyzes the conversion of cortisol and its metabolites; 11β-HSD2 is a specific oxidase that catalyzes only Cortisol inactivation. 11β HSD1 widely distributed in the body, the function is not yet clear. 11β HSD2 mainly in mineralocorticoid target organs, kidney 11β HSD2 by degrade glucocorticoid mineralocorticoid receptor specificity, the lack of this enzyme in the kidney, can lead to severe hypertension. Placental 11β HSD2 through the degradation of the mother of high concentrations of glucocorticoids to ensure the normal development of the fetus, placental abnormalities in this enzyme can lead to intrauterine growth retardation. This enzyme may also be related to stress, diabetes, degenerative neurodegeneration and the like