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未分化小细胞肺癌为各种组织类型肺癌中倍增时间最短、增殖最快、恶性最高、早期就有转移的一种类型。我院自1981年初至1987年初共收治本病96例,现报告如下。 一、材料及方法 96例均经病理证实,其中男69例,女27例,男:女为3:1;年龄自14～75岁,最小14岁,最长75岁,平均40.3岁。临床广泛型68例(70％),局限型28例(29.2％)。 本组96例随机分为四组,用四种方案化疗,计CCOM(环磷酰胺CTX、环己亚硝 CCNU、长春新硷VCR、甲氨喋呤MTX)组41例;COD(环磷酰胺长春新硷、阿霉素ADM)组30例;COM(环磷酰胺、长春新硷、甲氨喋呤)组15例;COF(环磷酰胺、长春新硷、5—氟脲嘧啶5—FU)组10例。方法为CCDM组第一天晚空腹口服CCNU80mg/m~2。第二天四组分别为CTX1000
Undifferentiated small cell lung cancer is the type with the shortest doubling time, the fastest proliferation, the highest malignant, and early metastasis in lung cancer of various tissue types. Our hospital has treated 96 cases of this disease from early 1981 to early 1987. The current report is as follows. First, materials and methods 96 cases were confirmed by pathology, including 69 males and 27 females, male: female 3:1; age from 14 to 75 years old, minimum 14 years old, up to 75 years old, average 40.3 years old. Clinically extensive 68 cases (70%), localized 28 cases (29.2%). This group of 96 patients were randomly divided into four groups, with four regimen chemotherapy, including CCOM (cyclophosphamide CTX, cyclohexyl nitrite CCNU, Changchun neonatal VCR, methotrexate MTX) group of 41 patients; COD (cyclophosphamide 30 patients were treated with Changchun Xinhao and Adriamycin (ADM) group; 15 patients were treated with COM (cyclophosphamide, vinorelbine, methotrexate); COF (cyclophosphamide, vinorelbine, 5-fluorouracil 5-FU) ) 10 cases. METHODS: The CCDM group received oral CCNU 80 mg/m 2 on the first day of fasting. The next day the four groups were CTX1000