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目的:探讨Ku70在宫颈胞癌组织中的表达水平与宫颈癌发生、发展的关系。方法:应用免疫组化方法检测Ku70蛋白在15例正常宫颈组织、30例宫颈上皮内瘤变、56例宫颈鳞癌组织中的表达。结果:Ku70在正常宫颈组织、宫颈上皮内瘤变和宫颈癌组织中都有不同程度的表达,但宫颈癌组织中Ku70的表达明显高于正常宫颈组织和宫颈内瘤变,且宫颈癌组织分化程度越差则Ku70的阳性率越高,表达强度越强;不同组织类型的宫颈癌Ku70的表达无差异。结论:Ku70蛋白可能在宫颈癌的发生、发展过程中起重要作用。
Objective: To investigate the relationship between the expression of Ku70 in cervical carcinoma and the occurrence and development of cervical cancer. Methods: The expression of Ku70 protein in 15 cases of normal cervical tissue, 30 cases of cervical intraepithelial neoplasia and 56 cases of cervical squamous cell carcinoma were detected by immunohistochemistry. Results: Ku70 expression in normal cervical tissue, cervical intraepithelial neoplasia and cervical cancer tissues were different, but the expression of Ku70 in cervical cancer tissues was significantly higher than that in normal cervical tissues and cervical intraepithelial neoplasia, and cervical cancer tissue differentiation The worse the degree, the higher the positive rate of Ku70, the stronger the expression intensity. There was no difference in the expression of Ku70 in different types of cervical cancer. Conclusion: Ku70 protein may play an important role in the occurrence and development of cervical cancer.