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目的观察直肠半结扎模型大鼠肺组织中血管活性肠肽(VIP)、神经激肽A(NKA)及肠三叶因子(TFF3)含量变化及通腑中药(大承气汤)对其的调节作用,探讨“肺合大肠”神经肽机制。方法制备直肠半结扎大鼠模型。50只清洁级SD大鼠随机分为正常组、持续结扎组、解扎组、解扎给药组、正常给药组,给药组灌胃大承气汤3 g/只。检测各组大鼠支气管肺泡灌洗液(BALF)中肿瘤坏死因子(TNF-α)、血清白细胞介素-1β(IL-1β)及肺组织中VIP、TFF3、NKA的含量。结果模型组大鼠BALF中TNF-α、IL-1β及肺组织中NKA、TFF3含量均明显升高(P<0.01),VIP含量明显降低(P<0.01)。经大承气汤从肠干预后,BALF中TNF-α、IL-1β及肺组织中NKA、TFF3含量均明显降低(P<0.01),VIP含量明显升高(P<0.01)。Pearson correlation分析显示肺组织中NKA、VIP、TFF3含量与BALF中TNF-α、IL-1β含量明显相关(P<0.01或P<0.05)。结论通腑疗法可减轻直肠半结扎模型大鼠的肺部炎症,这一效应的产生与肺组织中VIP、TFF3、NKA含量的变化密切相关。
Objective To observe the changes of contents of vasoactive intestinal peptide (VIP), neurokinin A (NKA) and intestinal trefoil factor (TFF3) in the lung tissue of rats with rectal semiligation and the regulation of Tongfu Traditional Chinese Medicine (Dachengqi Decoction) Role, to explore “pulmonary colorectal ” neuropeptide mechanism. Methods The rat model of rectum ligation was prepared. Fifty clean-grade SD rats were randomly divided into normal group, continuous ligation group, untreated group, untreated group, normal administration group, and administered group Dachengqi Decoction 3 g / only. The levels of tumor necrosis factor (TNF-α), serum interleukin-1β (IL-1β) and the contents of VIP, TFF3 and NKA in bronchoalveolar lavage fluid (BALF) Results The levels of TNF-α, IL-1β in BALF and the levels of NKA and TFF3 in lung tissue of model group were significantly increased (P <0.01), while the content of VIP was significantly decreased (P <0.01). The contents of TNF-α, IL-1β in BALF and NKA, TFF3 in lung tissue were significantly decreased (P <0.01) and VIP content was significantly increased (P <0.01) after Dachengqi decoction was administered from intestine. Pearson correlation analysis showed that the levels of NKA, VIP and TFF3 in lung tissue were significantly correlated with the levels of TNF-α and IL-1β in BALF (P <0.01 or P <0.05). Conclusion Tongfu therapy can relieve lung inflammation in the rats with rectal semi-ligation, which is closely related to the changes of VIP, TFF3 and NKA in lung tissues.