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研究抗癌新药的试验室人员和临床化疗医生早已意识到,没有一个动物肿瘤系统,也没有异种移植或体外人体肿瘤细胞系,可以作为人体肿瘤对药物反应的理想预测工具,而对人体和小鼠药物疗法进行体内药效动力学研究很困难,同样作体外研究也不容易.肿瘤模型有时不足以作为选择临床活性强的治癌新药的依据,因此有必要改进方法和采用新技术来探索抗肿瘤新药.但扬弃传统的动物系统也应谨慎,因为继
The laboratory staff and clinical chemotherapy physicians who have researched new anticancer drugs have long realized that there is no animal tumor system, no xenotransplantation or in vitro human tumor cell lines, and can be used as an ideal tool for predicting the response of human tumors to drugs. In vivo pharmacodynamic studies of murine drug therapy are difficult, and in vitro studies are not easy. Tumor models are sometimes not sufficient as a basis for selecting new clinically active cancer drugs. Therefore, it is necessary to improve methods and adopt new technologies to explore resistance. New drugs for tumors. However, discarding traditional animal systems should also be cautious because