Early difference in apoptosis of intestinal mucosa of rats with severe uncontrolled hemorrhagic shoc

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Hemorrhagic shock is a common clinical emergency case. Successful treatment is usually accomplished by surgical control of hemorrhage and restoration of tissue perfusion. The fluid resuscitation method in the presurgical care of the hypotensive trauma patients is controversial.Current guidelines for presurgical treatment of patients with hemorrhagic shock recommend rapid volume resuscitation to normal blood pressure as quickly as possible. The practice is controversial because aggressive restoration of intravascular volume and rapid increase of blood pressure before securing hemostasis may exacerbate hemorrhage and worsen outcome. Controlled fluid resuscitation allows pre-hospital treatment to work with compensatory mechanisms. The concept is to restore some intravascular fluid while respecting hemostatic mechanisms. Such a scheme would balance the mutually exclusive processes of tissue perfusion and hemostasis.
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