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目的:探讨硫糖铝和黄连素联合治疗慢性顽固性胃炎的临床效果。方法:选取156例慢性顽固性胃炎患者。随机均分为对照组和治疗组。对照组给予枸椽酸铋钾颗粒联合克拉霉素分散片治疗,治疗组给予硫糖铝联合黄连素治疗。观察两组患者的临床治疗效果、不良反应情况及治疗前后患者幽门螺旋杆茵检测的变化。同时对所有患者随访1年,观察复发情况。结果:治疗组患者总有效率、幽门螺旋杆茵转阴率、复发率均优于对照组,差异显著(P<0.05)。结论:硫糖铝联合黄连素治疗慢性顽固性胃炎具有良好的临床治疗效果。HP转阴率高,复发率低,值得临床推广。
Objective: To investigate the clinical effect of sucralfate and berberine in the treatment of chronic intractable gastritis. Methods: 156 patients with chronic intractable gastritis were selected. Randomly divided into control group and treatment group. The control group was treated with bismuth potassium citrate granules combined with clarithromycin dispersible tablets, the treatment group was given sucralfate combined with berberine. The clinical efficacy, adverse reactions and changes of Helicobacter pylori in both groups before and after treatment were observed. At the same time all patients were followed up for 1 year to observe the recurrence. Results: The total effective rate of the treatment group, the negative conversion rate of Helicobacter pylori and recurrence rate were better than the control group, the difference was significant (P <0.05). Conclusion: Sucralfate combined with berberine has a good clinical effect in the treatment of chronic intractable gastritis. HP high negative rate, low recurrence rate, worthy of clinical promotion.