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Brn-3a转录因子主要表达于周围神经系统的神经元亚群中,参与神经元的生存和分化相关基因的激活。对Brn-3a的调节包括启动子调节、磷酸化和尤文氏肉瘤蛋白的激活作用。而Brn-3a对神经细胞的调节包括抑制bHLH基因NeuroD4(Math3)和NeuroD1、影响p53的作用、激活α-Internexin启动子、控制感觉神经元中酪氨酸激酶受体A(TrkA)表达及与甾体激素受体共活化物(Src-1)交互作用等。人乳头瘤病毒(HPV)感染是导致宫颈癌的关键因素。已有研究表明Brn-3a与人乳头瘤病毒感染后引起的宫颈细胞癌变有关。但其具体机制及与不同型别人乳头瘤病毒感染的关系等尚有待进一步研究。
The Brn-3a transcription factor is mainly expressed in the neuronal subpopulation of the peripheral nervous system and is involved in the activation of neuronal survival and differentiation-related genes. Regulation of Brn-3a includes promoter regulation, phosphorylation, and activation of Ewing’s sarcoma protein. The regulation of Brn-3a on neural cells includes the inhibition of the bHLH gene NeuroD4 (Math3) and NeuroD1, the effect of p53, the activation of the α-Internexin promoter, the control of the expression of tyrosine kinase receptor A (TrkA) in sensory neurons and Steroid hormone receptor coactivator (Src-1) interaction and so on. Human papillomavirus (HPV) infection is a key factor leading to cervical cancer. It has been reported that Brn-3a is associated with canceration of cervical cells caused by human papillomavirus (HPV) infection. However, its specific mechanism and different types of human papillomavirus infection remains to be further studied.