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经过近40年的发展,儿童髓系白血病的生存率显著上升。生存率的增长有赖于以下因素:对细胞遗传学及早期治疗反应等预后危险因素更深刻的认知,对疾病危险分组更为准确;化疗方案的优化,包括化疗剂量的强化、传统诱导化疗天数的延长等;新型化疗药物,如靶向药物的出现;造血干细胞移植的进展。文章主要综述以上各因素的研究进展。[临床儿科杂志,2012,30(5):487-491]
After nearly 40 years of development, the survival rate of children’s myeloid leukemia increased significantly. Survival rate growth depends on the following factors: a more profound understanding of prognostic risk factors such as cytogenetics and early response to treatment, and a more accurate diagnosis of disease risk groups; optimization of chemotherapy regimens including enhancement of chemotherapy dose, days of traditional induction chemotherapy Such as the extension of new chemotherapeutic drugs, such as the emergence of targeted drugs; the progress of hematopoietic stem cell transplantation. The article mainly summarizes the research progress of the above factors. [Journal of Clinical Pediatrics, 2012,30 (5): 487-491]