小檗碱(berberine,BR)又称黄连素,为毛茛科黄连属植物黄连、黄柏的根茎中提取的异喹啉类生物碱,属季铵类化合物。上世纪50~60年代已有其可抑制癌细胞对羟胺的利用,从而抑制嘌呤及核酸合成的报道[1],近几年研究发现,BR具有细胞毒性,可以通过抑制癌细胞的蛋白合成、阻滞细胞周期? Berberine (berberine, BR), also known as berberine, is the isoquinoline alkaloids extracted from the rhizomes of Coptis and Coptis in Ranunculaceae and belongs to quaternary ammonium compounds. 50 ~ 60s of last century has been its inhibition of cancer cells on the use of hydroxylamine, thereby inhibiting purine and nucleic acid synthesis reported [1], in recent years found that BR has cytotoxicity can inhibit cancer cell protein synthesis, Block cell cycle?