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目的探讨莫沙必利联合复方阿嗪米特治疗功能性消化不良的临床疗效。方法选择2014年1月-2015年7月来河南省郸城县人民医院就诊的120例功能性消化不良患者作为研究对象,随机分为两组,每组60例。对照组采用莫沙必利治疗,观察组采用莫沙必利联合复方阿嗪米特治疗,连续治疗4周。比较两组治疗总有效率、症状改善情况及治疗后胃排空时间和水负荷量。采用SPSS 19.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05表示差异有统计学意义。结果治疗后观察组,总有效率和胃排空时间分别为93.33%和(42.26±5.21)min,对照组分别为78.33%和(51.83±9.66)min,差异有统计学意义(P<0.05)。观察组治疗后餐后不适、恶心呕吐、反酸、食欲不振及腹痛腹胀等症状评分显著低于治疗前和对照组治疗后,差异有统计学意义(P<0.05)。结论莫沙必利联合复方阿嗪米特可显著改善功能性消化不良患者餐后不适、腹胀腹痛、恶心呕吐及反酸等临床症状,缩短胃排空时间,效果显著。
Objective To investigate the clinical efficacy of mosapride combined with compound azinamamide in the treatment of functional dyspepsia. Methods A total of 120 patients with functional dyspepsia who visited Dancheng People’s Hospital of Henan Province from January 2014 to July 2015 were randomly divided into two groups (n = 60 in each group). The control group was treated with mosapride, and the observation group was treated with mosapride combined with compound azintm for 4 weeks. The total effective rate, symptom improvement, gastric emptying time and water load were compared between the two groups. Statistical analysis was performed using SPSS 19.0 statistical software. The measurement data were expressed as mean ± standard deviation (xˉ ± s), t test was used and the count data (%) was used. Chi-square test was used. P <0.05 was considered statistically significant . Results After treatment, the total effective rate and gastric emptying time were 93.33% and 42.26 ± 5.21 min in the observation group and 78.33% and 51.83 ± 9.66 min in the control group, respectively, with significant difference (P <0.05) . The score of symptom such as postprandial discomfort, nausea and vomiting, acid reflux, loss of appetite and abdominal distension in observation group after treatment were significantly lower than those before treatment and control group (P <0.05). Conclusion Mosapride combined with compound azinamazine can significantly improve clinical symptoms of post-prandial discomfort, abdominal distension and abdominal pain, nausea and vomiting and acid reflux in patients with functional dyspepsia, and shorten the time of gastric emptying, with a significant effect.