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目的：在与原发瘤癌细胞比较下，探讨转移对癌细胞的生物学特性的影响。方法：采用显微分光光度学和免疫组化，比较１０例鼻咽癌原发瘤和转移瘤中癌细胞的核型和分化程度。结果：多数病例转移性鼻咽癌细胞的ＤＮＡ指数、单位面积ＤＮＡ指数和＞５．０ＣＤＮＡ百分率均降低，而在少数病例中却反而升高。结论：鼻咽癌原发瘤与转移瘤癌细胞的核型和分化程度有差异，这是由于它们所在的部位不同所致，即一在鼻咽部，另一在淋巴结。
OBJECTIVE: To investigate the effects of metastasis on the biological characteristics of cancer cells in comparison with primary tumor cells. Methods: The karyotype and differentiation of cancer cells in 10 primary and metastatic nasopharyngeal carcinomas were compared by microdispectrophotometry and immunohistochemistry. Results: The DNA index, DNA index per unit area and the percentage of> 5.0 CDNA in most cases of metastatic NPC cells were decreased, but increased in a few cases. CONCLUSIONS: There are differences in the karyotype and differentiation of primary and metastatic NPC tumor cells due to their different sites, one in the nasopharynx and the other in the lymph nodes.