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目的评估他汀类联合心血管药物治疗冠心病的临床疗效及不良反应。方法 87例冠心病患者,按照不同给药方式分为对照组(43例)与实验组(44例)。对照组给予常规心血管药物进行治疗,实验组在对照组基础上给予他汀类药物治疗。对比观察两组临床疗效及不良反应。结果纳入病例均随访3~6个月,实验组中:显效25例(56.82%),有效17例(38.64%),无效2例(4.55%),总有效率为95.45%(42/44);对照组中:显效20例(46.51%),有效14例(32.56%),无效9例(20.93%),总有效率为79.07%(34/43)。实验组总有效率高于对照组,差异具有统计学意义(P<0.05)。实验组1例(2.27%)发生不良反应,对照组7例(16.28%)发生不良反应,实验组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论在对冠心病患者治疗时,他汀类联合心血管药物的应用效果明显,可在改善治疗有效率的基础上,防治不良反应发生。
Objective To evaluate the clinical efficacy and adverse reactions of statins combined with cardiovascular drugs in the treatment of coronary heart disease. Methods 87 patients with coronary heart disease were divided into control group (43 cases) and experimental group (44 cases) according to different administration methods. The control group was given conventional cardiovascular drugs for treatment, and the experimental group was given statins on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were observed. Results The cases were followed up for 3 to 6 months. In the experimental group, 25 cases (56.82%) were markedly effective, 17 cases (38.64%) were effective, 2 cases (4.55%) were ineffective, and the total effective rate was 95.45% In the control group, 20 cases were markedly effective (46.51%), 14 cases (32.56%) effective and 9 cases (20.93%) ineffective. The total effective rate was 79.07% (34/43). The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P <0.05). One patient (2.27%) in the experimental group had adverse reactions, and the other seven patients (16.28%) in the control group had adverse reactions. The incidence of adverse reactions in the experimental group was lower than that in the control group (P <0.05). Conclusions In the treatment of patients with coronary heart disease, the effect of statins combined with cardiovascular drugs is obvious, and the adverse reactions can be prevented and controlled on the basis of improving the treatment efficiency.