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β阻滞剂降低心率、血压,减弱心肌收缩,降低心肌耗氧量。因心率减慢,舒张期较长,有利于舒张期冠脉血流量。它不但用于慢性心肌缺血(心绞痛),也用于不稳定型心绞痛、中间型症候群病人,以期阻止这些濒临性心肌梗塞病例发生梗塞。当缺血过程已发展为不可逆时,它能否缩小梗塞范围,尚未明确。但用于早期缺血具有一定效果。但长期采用既有的一些β阻滞剂常有触发心衰、支气管痉挛、传导阻滞之虑。为此制药工业部门一直在研制、寻找新的β阻滞剂。
Beta blockers reduce heart rate, blood pressure, reduce myocardial contractility, reduce myocardial oxygen consumption. Due to slower heart rate, longer diastolic, is conducive to diastolic coronary blood flow. It is not only used for chronic myocardial ischemia (angina pectoris), but also for patients with unstable angina and intermediate syndrome, with a view to preventing infarction in these cases of threatened myocardial infarction. When the ischemic process has progressed to irreversible, it is not yet clear whether it will reduce infarct size. But for the early ischemia has some effect. But long-term use of some of the existing beta blockers often trigger heart failure, bronchospasm, block of the mind. To this end the pharmaceutical industry has been developing, looking for new beta blockers.