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同烧伤一样，机械性创伤时机体血清同样存在低分子量的免疫抑制物，我们发现并证实分子量约９０００的创伤血清抑制物对ＩＬ一２及ＩＬ－２Ｒ蛋白表达具有强烈的免疫抑制作用，且对ＩＬ－２和ＩＬ－２ＲｍＲＮＡ的转录也具有明显的抑制作用。从而揭示：这种创伤血清免疫抑制物对淋巴细胞的抑制作用发生于ｍＲＮＡ转录前水平，可能与细胞起始活化信号的识别和受阻有关。
As with burns, low molecular weight immunosuppressants are also present in the sera of patients with mechanical trauma and we have found and demonstrated that traumatic serum inhibitors with a molecular weight of about 9000 have a strong immunosuppressive effect on IL-2 and IL-2R protein expression, Transcription of IL-2 and IL-2R mRNA also has a significant inhibitory effect. This revealed that the immunosuppressive agents of this traumatic serum suppressed the lymphocytes to a pre-mRNA transcription level, which may be related to the recognition and inhibition of cell activation signals.