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目的:评价国产加替沙星注射液治疗机械通气并呼吸衰竭患者的临床疗效和安全性。方法:46例病人随机分为治疗组23例,给予加替沙星0．4 g静滴qd;对照组23例,给予头孢吡肟2．0 g,静滴bid;疗程10-14 d。结果:加替沙星组和头孢吡肟组的临床总有效率均为69．56％和73．91％,细菌清除率为78．26％和82．60％;不良反应发生率分别为8．7％,两组比较无统计学差异(P>0．05)。结论:加替沙星是一种安全有效的抗菌药,可推荐用于机械通气并呼吸衰竭患者的治疗。
Objective: To evaluate the clinical efficacy and safety of domestic gatifloxacin injection in the treatment of patients with mechanical ventilation and respiratory failure. Methods: Forty-six patients were randomly divided into treatment group (n = 23) and gatifloxacin 0.4 g intravenously (qd). Control group (n = 23) received cefepime 2.0 g once daily for 10-14 days. Results: The total effective rates of gatifloxacin group and cefepime group were 69.56% and 73.91%, the bacterial clearance rate was 78.26% and 82.60% respectively. The incidence of adverse reactions were 8 .7%, there was no significant difference between the two groups (P> 0.05). Conclusion: Gatifloxacin is a safe and effective antimicrobial agent that can be recommended for the treatment of patients with mechanical ventilation and respiratory failure.