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健康雌性家兔６只，于静注诺氟沙里（２５ｍｇ／ｋｇ）前、后不同时间收集血、胆汁、脑脊液和尿液标本。用ＨＰＬＣ法测定标本中的药物浓度，所得实验数据用３Ｐ８７药代动力学软件包在微机上进行处理。结果显示，静注给药后，诺氟沙星在体内的药代动力学过程符合二室开放模型：血清、胆汁、尿中的诺氟沙星浓度均大于大多数革兰氏阳性菌和阴性菌的ＭＩＣ９０，脑脊液中的诺氟沙星浓度（峰值）等于或略高于引起脑部感染常见敏感菌的ＭＩＣ９０，表明诺氟沙星静注后，诺氟沙星能较快地分布到。上述体液中，并达到有效杀菌浓度。
Six healthy female rabbits were collected blood, bile, cerebrospinal fluid and urine samples before and after intravenous injection of norfalizarin (25 mg / kg). The concentration of the drug in the sample was determined by HPLC. The experimental data obtained were processed on a microcomputer using the 3P87 pharmacokinetic software package. The results showed that after intravenous administration, norfloxacin pharmacokinetics in vivo in line with the two-compartment open model: serum, bile, urinary concentrations of norfloxacin were greater than most Gram-positive bacteria and negative The MIC90 of bacteria, the concentration (peak) of norfloxacin in cerebrospinal fluid, is equal to or slightly higher than the MIC90 of common sensitive bacteria causing brain infection, indicating that norfloxacin can be rapidly distributed after intravenous injection of norfloxacin. The above body fluids, and to achieve effective bactericidal concentration.