论文部分内容阅读
测定了10例健康人、20例肺良性疾病及15例肺癌患者血LPO含量、GSH-Px活性、SOD活性及SOD/LP0比值,结果①肺癌组SOD活性,SOD/LPO比值均显著低于正常组及良性组(P<0.01;<0.05;<0.01;<0.01);②正常组及良性组SOD活性及SOD/LPO比值差别无显著性(分别P>0.05);③LPO含量及GSH-Px活性三组之间差别无显著性(分别P>0.05);④若将正常组SOD及SOD/LPO比值的均数分别减去一个标准差(x-s)作为肺癌的诊断试验阳性标准,其灵敏度分别为73.3％和73.3％,特异度为80％和70％;诊断符合率为77.1％和71.4％。上述结果提示肺癌的发生发展可能与氧自由基损伤有关。通过SOD活性及SOD/LPO比值的测定可作为鉴别肺部良恶性疾病的辅助诊断手段之一,对肺癌的辅助诊断也有一定价值。
The LPO content, GSH-Px activity, SOD activity, and SOD/LP0 ratio were measured in 10 healthy subjects, 20 benign pulmonary diseases, and 15 lung cancer patients. Results 1 SOD activity and SOD/LPO ratio were significantly lower in the lung cancer group than normal Group and benign group (P<0.01; <0.05; <0.01; <0.01); 2 There was no significant difference in SOD activity and SOD/LPO ratio between normal group and benign group (P>0.05 respectively); 3LPO content and GSH-Px activity There was no significant difference between the three groups (P>0.05, respectively);4If the mean SOD and SOD/LPO ratios in the normal group were subtracted by one standard deviation (xs) respectively as the positive criteria for lung cancer diagnostic tests, the sensitivities were 73.3% and 73.3%, specificity was 80% and 70%; diagnostic compliance rate was 77.1% and 71.4%. The above results suggest that the development of lung cancer may be related to the damage of oxygen free radicals. The determination of SOD activity and SOD/LPO ratio can be used as one of the auxiliary diagnostic methods to distinguish between benign and malignant lung diseases. It also has a certain value for the diagnosis of lung cancer.