肝脏与血液凝固及纤溶系统有密切关系。因为在肝细胞内(除第Ⅷ因子外)几乎产生所有的凝血因子,所以重症肝炎及肝硬化等严重的肝疾病,因凝血因子产生减少而导致出血倾向。肝硬化时门静脉高压及脾肿大而出现血小板减少,并且随着肝纤维组织增生,纤溶活性亢进,这两者加剧了出血倾向。 Liver and blood coagulation and fibrinolysis system are closely related. Because almost all of the clotting factors are produced in the liver cells (except for the factor VIII), severe liver diseases such as severe hepatitis and cirrhosis cause a tendency to bleed due to a decrease in the production of blood coagulation factors. Cirrhosis portal hypertension and splenomegaly and thrombocytopenia, and with the proliferation of liver fibrosis, fibrinolytic activity hyperthyroidism, both exacerbated bleeding tendency.