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目的:研究鸡内金多糖(PECG)对糖尿病高脂血症模型的影响。方法:以高脂高糖饲料饲喂Wistar大鼠30 d后,腹腔注射链脲佐菌素,继续以高脂高糖饲料饲喂,并分别以80,20 mg.kg-1剂量的鸡内金多糖灌胃给药40 d,测定血清血脂和血糖水平,计算胸腺指数和脾脏指数,检测淋巴细胞增殖能力,考察PECG对大鼠血脂、血糖及免疫功能的影响。结果:PECG能显著降低糖尿病高脂血症大鼠总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平和空腹血糖浓度(P<0.05),升高高密度脂蛋白胆固醇(HDL-C)、胸腺指数及脾指数(P<0.05),高剂量组大鼠的淋巴细胞转化能力增强,刺激指数(SI)明显升高(P<0.05)。结论:PECG能有效降低糖尿病高脂血症大鼠血糖和血脂水平,并能改善其细胞免疫功能。
Objective: To study the effect of PECG on diabetic hyperlipidemia model. Methods: Wistar rats were fed with high-fat and high-sugar diet for 30 days. After intraperitoneal injection of streptozotocin, rats were fed with high-fat and high-sugar diet, and fed with 80, 20 mg.kg-1 Gold polysaccharide was administered intragastrically for 40 days. Serum lipids and blood glucose levels were measured. Thymus index and spleen index were calculated. Proliferation of lymphocytes was measured. The effects of PECG on blood lipid, blood glucose and immune function were investigated. Results: PECG could significantly decrease the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (P <0.05) in diabetic hyperlipidemic rats, (HDL-C), thymus index and spleen index (P <0.05). The lymphocyte transformation ability of high-dose group was enhanced and the stimulation index (SI) was significantly increased (P <0.05). Conclusion: PECG can effectively reduce the level of blood glucose and blood lipid in diabetic rats with hyperlipemia and improve its cellular immune function.