作者报告在一组105例慢淋病例中有2例分别于诊断后6年和15年发展为多发性骨髓瘤。例1为75岁女性,因疲乏无力,体重减轻于1965年1月住院,体检发现两侧腋下数个淋巴结约1厘米,肝可触及。贫血、末梢血淋巴细胞增多,胸骨穿刺淋巴细胞占91%,未发现浆细胞,诊断为慢淋。给予瘤可宁,前后治疗5年。1971年9月患者右第6肋骨疼痛,1972年11月检查发现该部位有溶骨性损害,诊断为多发性骨髓瘤IgA K型。双侧髂后穿刺淋巴细胞30%,浆细胞24%。应用间接免疫荧光染色显示浆细胞内含IgA。病理切片上见成堆浆细胞 The authors report that two of 105 patients with chronic lymphocytic leukemia developed multiple myeloma at 6 and 15 years after diagnosis, respectively. Example 1: A 75-year-old woman was hospitalized in January 1965 due to fatigue and weight loss. About a few centimeters of axillary lymph nodes were found on both sides of the body and the liver was palpable. Anemia, peripheral blood lymphocytes, breast sperm lymphocytes accounted for 91%, found no plasma cells, the diagnosis of chronic leaching. Give tumor Ning, before and after treatment for 5 years. In September 1971, the right 6th rib was painful in the patient. In November 1972, it was found that the site had osteolytic lesions and was diagnosed as IgA K type of multiple myeloma. Bilateral posterior iliac puncture of lymphocytes 30%, plasma cells 24%. Indirect immunofluorescence staining showed that plasma cells contained IgA. Pathological sections see piles of plasma cells