目的　探讨肝硬化患者纤溶活性增高与组织纤溶酶原激活物 (t- PA)、组织纤溶酶原激活物抑制剂(PAI)的关系。方法　根据 Child- Pugh分级将确诊为肝硬化的 86例患者分为三组 ,A级组 2 6例 ,B级组 30例 ,C级组 30例。均检测 t- PA、PAI、纤维蛋白 (原 )降解产物 (FDP)和 D-二聚体。结果　三组 t- PA抗原随病情严重程度而显著性升高 ,有显著性差异 (P<0 .0 5 ) ;PAI活性三组近似 (P>0 .0 5 ) ;纤溶活性高者的 t- PA略高于正常纤溶者 ,且二者 PAI近似 ,均无显著性差异 (P>0 .0 5 )。结论　 t- PA随病情加重而显著性升高 ,PAI随病情加重变化不大 ;t- PA、PAI失平衡不是肝硬化患者纤溶活性升高的主要因素。 Objective To investigate the relationship between increased fibrinolytic activity and tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor (PAI) in patients with liver cirrhosis. Methods According to Child-Pugh classification, 86 patients diagnosed with cirrhosis were divided into three groups: 26 cases in group A, 30 cases in group B and 30 cases in group C. Both t-PA, PAI, fibrinogen (FDP) and D-dimer were detected. Results The levels of t-PA antigen in three groups were significantly increased with the severity of the disease (P <0.05), PAI activity in the three groups was similar (P> 0.05), fibrinolytic activity t-PA slightly higher than normal fibrinolysis, and the two PAI approximation, no significant difference (P> 0.05). Conclusions t PA increases significantly with the aggravation of the disease. PAI does not change much with the aggravation of disease. The imbalance of t PA and PAI is not the main factor of fibrinolytic activity in patients with cirrhosis.