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目的 探讨FasL及pRb在视网膜母细胞瘤中的表达及意义。方法 用免疫组织化学SP方法检测45例视网膜母细胞瘤及12例正常视网膜组织中FasL及pRb蛋白的表达。结果 视网膜母细胞瘤组织表达pRb,比正常组织显著降低(P=00009)。视网膜母细胞瘤和正常组织均高表达FasL。结论 FasL的表达是贯穿视网膜母细胞瘤发生及发展过程中的一个重要事件,pRb低表达与肿瘤的发生有密切关系。
Objective To investigate the expression and significance of FasL and pRb in retinoblastoma. Methods The expressions of FasL and pRb protein in 45 cases of retinoblastoma and 12 cases of normal retinal tissue were detected by immunohistochemical SP method. Results The expression of pRb in retinoblastoma tissue was significantly lower than that in normal tissue (P = 00009). Both retinoblastoma and normal tissues express FasL overexpressing. Conclusion The expression of FasL is an important event throughout the development and progression of retinoblastoma. The low expression of pRb is closely related to tumorigenesis.