动脉粥样硬化是由于脂代谢紊乱而引起的一些大、中型动脉壁发生的病变,主要损害管壁的内层结构,病变部位是一些由增殖的平滑肌细胞和透入其中的巨噬细胞形成的斑块,许多细胞摄入了大量由低密度脂蛋白来源的胆固醇酯,胞质中出现特征性的泡沫结构.关于这种斑块病变的形成机制,通常认为是血管壁损伤和修复相互作用而缓慢形成的继发现象.损伤由一些危害因素所引起,如高胆固醇血症、高 Atherosclerosis is a disorder of some large and medium arterial walls caused by disturbance of lipid metabolism, which mainly damages the inner structure of the tube wall. Some of the lesions are formed by proliferating smooth muscle cells and macrophages penetrating into it Plaques, many cells ingest large amounts of cholesteryl esters derived from low-density lipoproteins, and a characteristic foam structure appears in the cytoplasm. The formation mechanism of this plaque lesion is generally considered to be an interaction between vascular wall injury and repair Slowly formed secondary phenomenon. Damage caused by a number of hazards, such as hypercholesterolemia, high