神经母细胞瘤,除了已知的年龄及肿瘤分期等预后因素外,作者认为肿瘤染色体组型对判断该肿瘤的预后可能是重要的。为此,作者在获得14例儿童神经母细胞瘤细胞学基因资料的基础上,应用直接染色体制备或短期细胞培养方法,对28例不同分期的神经母细胞瘤患儿肿瘤染色体组型进行分析,同时对其中的10个病例进行原始肿瘤基因N-myc DNA分析。结果表明,18例Ⅳ期神经母细胞瘤病人有15例,3例Ⅲ期病人有2例肿瘤染色体组型出现1号染色体短臂异常,最常见断裂点 Neuroblastoma, in addition to known prognostic factors such as age and stage of the tumor, the authors suggest that the chromosomal pattern of the tumor may be important in determining the prognosis of the tumor. Therefore, based on the data of 14 children with neuroblastoma cytology, the authors used direct chromosome preparation or short-term cell culture method to analyze the tumor genome of 28 children with different stages of neuroblastoma, Meanwhile, the original tumor gene N-myc DNA was analyzed in 10 of them. The results showed that in 18 cases of Ⅳ neuroblastoma patients in 15 cases, 3 cases of Ⅲ patients there are 2 cases of tumor chromosome type 1 chromosome short arm anomalies, the most common point of rupture