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目的:研究活络通脑片对脑卒中的预防作用。方法:分别考察活络通脑片对大鼠动静脉旁路血栓形成、大鼠血小板聚集及高血压合并高血脂大鼠脑动脉硬化模型的影响。结果:活络通脑片中、高剂量能显著抑制大鼠动静脉旁路血栓的形成及大鼠全血血小板聚集度(P<0.05),抑制率分别为17.71%、22.69%和20.34%、24.43%;活络通脑片预防给药能显著抑制动静脉血栓的形成;活络通脑片各剂量均能显著降低高血压合并高血脂致脑动脉硬化模型大鼠CHOz水平,高剂量能显著降低TGz、LDL-C水平,中剂量有一定的降血压作用,中、高剂量能降低全血低切(ηbL)、ηP、ηr(B/P),高剂量能降低中切(ηbM)、红细胞聚集指数(AI)、卡松屈服应力(CY),对脑血管病变也有较好的改善作用,可显著抑制脑血管动脉硬化症状的形成。活络通脑片对大鼠血脂、血压和血液流变学的作用呈一定的量效关系,起效剂量为中剂量。结论:活络通脑片中剂量(生药1.28 g/kg)为起效剂量,对脑卒中具有一定的预防作用。
Objective: To study the preventive effect of Huoluo Tongnao Tablet on stroke. Methods: The effects of Huoluo Tongnao Tablet on the arteriovenous bypass thrombosis in rats, the platelet aggregation in rats and the model of cerebral arteriosclerosis in hypertensive rats were respectively investigated. Results: The high and middle dose of Huoluo Tongnao Tablet could significantly inhibit the formation of rat arteriovenous bypass thrombosis and rat platelet aggregation (P <0.05), the inhibition rates were 17.71%, 22.69% and 20.34%, 24.43 %; Tonglian Tongnao Tablet can significantly inhibit the prevention of arterial and venous thrombosis; all the doses of Huoluo Tongnao Tablet can significantly reduce the level of CHOz in hypertensive rats with cerebral arteriosclerosis caused by hyperlipidemia, LDL-C and middle dose could lower the blood pressure, middle and high dosage could decrease whole blood low cut (ηbL), ηP, ηr (B / P), high dose could reduce the middle cut (ηbM), erythrocyte aggregation index (AI), cardone yield stress (CY), have a better effect on cerebrovascular disease, can significantly inhibit the formation of cerebrovascular arteriosclerosis symptoms. The effect of Huoluo Tongnao Tablet on blood lipids, blood pressure and hemorheology in rats showed a certain dose-effect relationship, and the effective dose was medium dose. Conclusion: The active dose of Huoluo Tongnao Tablet (crude drug 1.28 g / kg) is the effective dose, which has a certain preventive effect on stroke.