【摘 要】
：
MicroRNAs (miRNAs),some small non-coding RNAs that regulate gene expression at the posttran-scriptional level,are always aberrantly expressed in carcinomas.In t
【机 构】
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Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China“,
论文部分内容阅读
MicroRNAs (miRNAs),some small non-coding RNAs that regulate gene expression at the posttran-scriptional level,are always aberrantly expressed in carcinomas.In this study,we found that miR-23b-3p was remarkably up-regulated in human esophageal squamous cell carcinoma cells and tissues.Moreover,miR-23b-3p could induce the proliferation,invasion,and metastasis in vitro.EBF3 was identified as the direct downstream target gene of miR-23b-3p and ectogenic EBF3 could strongly inhibit the proliferation,invasion,and metastasis in vitro.Furthermore,it was found that miR-23b-3p could regulate epithelial-to-mesenchymal transition progress by blocking EBF3.Therefore,it was concluded that miR-23b-3p targeted EBF3 to accelerate the proliferation,invasion,and metastasis in ESCC.
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