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为评价强噪声暴露后体内自由基引起的脂质过氧化反应的变化，将豚鼠６０只随机分为５组，２组正常对照，３组暴露噪声（１２６ｄＢＳＰＬ，３ｈ／ｄ，连续５ｄ或１０ｄ）。豚鼠血清超氧化物歧化酶（ＳＯＤ）的活力、血清丙二醛（ＭＤＡ）和全血谷胱甘肽（ＧＳＨ）的含量。结果发现，噪声暴露５ｄ，血清ＳＯＤ增加；暴露１０ｄ，ＳＯＤ降低（Ｐ都大于０．０５）。ＭＤＡ的含量随暴露时间延长增加（Ｐ＜０．０５）；ＧＳＨ的含量随暴露时间的延长降低（Ｐ＜０．０１）。表明，强噪声暴露后自由基引起的脂质过氧化反应增强。提示，应用自由基清除剂和抗氧化剂有可能预防或减轻噪声引起的损伤
To evaluate the changes of free radical-induced lipid peroxidation in rats after exposure to strong noise, 60 guinea pigs were randomly divided into 5 groups and 2 normal controls. The exposure noise (126dBSPL, 3h / d, 5d or 10d) . The levels of serum superoxide dismutase (SOD), serum malondialdehyde (MDA) and whole blood glutathione (GSH) in guinea pigs were determined. The results showed that the serum SOD increased 5 days after exposure to noise and SOD decreased (P> 0.05) 10 days after exposure. The content of MDA increased with the prolongation of exposure time (P <0.05). The content of GSH decreased with the prolongation of exposure time (P <0.01). It is suggested that the free radical induced lipid peroxidation increases after exposure to strong noise. Tip, the use of free radical scavengers and antioxidants may prevent or reduce noise-induced damage